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  1. Home
  2. » Blog
  3. » 2017

Blog Archive: March 2017

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Publication in PNAS

March 28, 2017
Lauren Ataman-M...

Dr. Francesca Duncan and her colleagues recently published in the Proceedings of the National Academy of Sciences (PNAS). 

This paper "mTORC1/2 Inhibition Preserves Ovarian Function and Fertility during Genotoxic Chemotherapy" is significant for the following reasons: "A major unresolved issue for premenopausal women undergoing chemotherapy is infertility due to the loss of nonrenewable ovarian primordial follicles. We show that pharmacologic down-regulation of the mammalian/mechanistic target of rapamycin (mTOR) pathway during chemotherapy in a mouse model prevents activation of primordial follicles, preserves ovarian function, and maintains normal fertility using clinically available inhibitors of mTOR complex (C)1 and mTORC1/2. These findings represent a feasible pharmacologic approach for preservation of ovarian function and fertility during treatment with conventional chemotherapy."

Click here to read the full paper.

Northwestern University's Feinberg School of Medicine press release regarding the publication is available here. 

Categories: 

  • In the news, Publication, Research, science

New Report in Toxicological Sciences

Lauren Ataman-M...
March 27, 2017

A New You, That's Who

Lauren Ataman-M...
March 23, 2017

Watch the March VGR Now!

Lauren Ataman-M...
March 16, 2017

LIVESTRONG launches new online training

Brigid Martz Smith
March 1, 2017

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The contents of the Oncofertility Consortium Blog are for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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